| The inventive subject matter
relates to methods for treating prostate cancer, comprising administration
of a composition comprising therapeutically effective amounts of supercritical
extracts of turmeric.Prostate Cancer. Prostate cancer is the third most
common cause of death from cancer in men of all ages and is the most common
cause of death from cancer in men over 75 years old. Prostate cancer
is rarely found in men younger than 40. Men at higher risk include black
men older than 60, farmers, tire workers, painters, and men exposed to
cadmium. The lowest incidence occurs in Japanese men and vegetarians. The
cause of prostate cancer is unknown, although some studies have shown a
relationship between high dietary fat intake or increased testosterone
levels.
Prostate cancer is a serious
and often life-threatening condition. Prostate cancer, which is characterized
by rapidly-proliferating cell growth, continues to be the subject of worldwide
research efforts directed toward the identification of therapeutic agents
which are effective in the treatment thereof. Effective therapeutic agents
prolong the survivability of the patient, inhibit the rapidly-proliferating
cell growth associated with the disease, or effect a regression of the
disease. Research in this area is primarily focused on identifying agents
which are therapeutically effective in humans and other mammals.
With prostate cancer, as
with all solid tumors, it is the metastatic encroachment of the tumor on
other vital function that causes the demise of the patient. Approximately
10% of patients are diagnosed initially with metastatic disease. Ultimately,
30–40% of patients with this cancer will develop metastatic disease. Once
metastasis occurs, the cancer follows a relentless progression unless interrupted
by effective treatment. Prostate cancers are classified based on their
aggressiveness and how different they are from the surrounding prostate
tissue. There are several different ways to classify tumors; one of the
more common is the Whitmore-Jewett system, in which tumors are rated as
follows:
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o A: tumor is unable to be felt on physical examination, and is usually
detected by accident after prostate surgery done for other reasons.
o B: tumor is confined to the prostate and usually detected by physical
examination or PSA testing.
o C: extension of tumor beyond the prostate capsule without spread to lymph
nodes.
o D: cancer has metastasized to regional lymph nodes or other parts of
the body, such as the bone and lungs for example.
With the advent of Prostate
Specific Antigen (hereinafter “PSA”) testing, most prostate cancers are
now found before they cause symptoms. The symptoms listed below are possible
indicators of prostate cancer: urinary hesitancy, urinary dribbling, urinary
retention, pain with urination, pain with ejaculation, lower back pain,
pain with bowel movement, excessive urination at night, incontinence, bone
pain or tenderness, hematuria, abdominal pain, anemia, weight loss, and
lethargy.
The appropriate treatment
of prostate cancer is often controversial. Treatment options vary based
on the stage of the tumor. In the early stages, surgical removal of the
prostate and radiation therapy may be used to eradicate the tumor. Metastatic
cancer of the prostate may be treated by hormonal manipulation, reducing
the levels of testosterone by drugs or removal of the testes, or by chemotherapy.
The inventive subject matter
is based on the discovery that a combination of certain herbs properly
extracted and blended in appropriate proportions can used in treating prostate
neoplasia. Thus, the present inventive subject matter relates to a method
for treating prostate neoplasia in a subject, comprising the step of administering
an effective amount of a composition to said subject to treat or prevent
said prostate neoplasia, said composition comprising therapeutically effective
amounts of supercritical extracts of turmeric.
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